Aldosterone/Plasma Renin Activity Ratio, LC/MS/MS

Test Code

Aldosterone, Plasma Renin Activity, Aldosterone/Plasma Renin Activity Ratio

Preferred Specimen
1.8 mL frozen plasma collected in an EDTA (lavender-top) tube

Minimum Volume
0.8 mL

Transport Container
Plastic screw-cap vial

Transport Temperature

Specimen Stability
Room temperature: 24 hours
Refrigerated: 24 hours
Frozen: 28 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Plasma separator tube (PST)

Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range
Upright 8:00-10:00 A.M. ≤28 ng/dL
Upright 4:00-6:00 P.M. ≤21  ng/dL
Supine 8:00-10:00 A.M. 3-16 ng/dL
1-12 Months 2-70 ng/dL
1-4 Years 2-37 ng/dL
5-9 Years ≤9 ng/dL
10-13 Years ≤21 ng/dL
14-17 Years ≤35 ng/dL
Premature (31-35 Weeks) ≤144 ng/dL
Term ≤217 ng/dL
Tanner Stages    
II-III Males 1-13 ng/dL
II-III Females 2-20 ng/dL
IV-V Males 3-14 ng/dL
IV-V Females 4-32 ng/dL

Plasma Renin Activity 0.25-5.82 ng/mL/h
Aldosterone/PRA Ratio 0.9-28.9 Ratio

Clinical Significance
The Aldosterone-renin ratio is used to screen for primary aldosteronism.

Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Dr
Chantilly, VA 20153

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.