Oxycodone and Metabolite, Quantitative, Serum

Test Code

18885

Includes

Oxycodone and Oxymorphone

Preferred Specimen

5 mL serum collected in a red-top tube (no gel)

Minimum Volume

3 mL

Instructions

Do not use serum separator tubes.

Transport Container

Plastic screw-cap vial

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 7 days
Refrigerated: 7 days
Frozen: 7 days

Methodology
Chromatography/Mass Spectrometry

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Set up: Mon, Wed, Fri; Report available: 3-5 days

Reference Range

Oxycodone

10-100 ng/mL

Oxymorphone
Peak plasma concentrations 1 hour after a single immediate-release tablet containing 5 mg of Oxycodone: 9-38 ng/mL.
Peak plasma concentrations within 2.5 hours after 10 mg of immediate-release preparation of Oxycodone: 13-46 ng/mL.
Mean peak plasma concentrations following a single dose of a 40 to 80 mg controlled-release Oxycodone preparation: 39-100 ng/mL.
Toxicity may be significant at greater than 200 ng/mL.
However, concentrations associated with toxicity are variable and depend on an individual's tolerance to the drug.

Clinical Significance

For therapeutic drug monitoring of oxycodone (Oxycontin®, Percocet®, Percodan®). Oxycodone is a semisynthetic opioid analgesic. Steady state concentration is reached in 24-36 hours after initiation of therapy. Elimination half-life of oxycodone is 4.5 hours for controlled release and 3.2 hours for immediate release formulations. Peak plasma concentration of oxycodone is 11, 21, 39, 99, or 156 ng/mL after a single oral dose of 10, 20, 40, 80, or 160 mg respectively. Oxymorphone is a minor but active metabolite of oxycodone that is present at lower concentration in the circulation. Therapeutic concentrations for oxymorphone have not been established.

Performing Laboratory

Quest Diagnostics Nichols Institute Valencia
27027 Tourney Road
Valencia, CA 91355-5386

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.