5-Hydroxyindoleacetic Acid (5-HIAA), Random Urine

Test Code
2637

Includes
(Serotonin)

Preferred Specimen
10 mL random urine with 6N HCl, submitted in a plastic, leak-proof container

Minimum Volume
5 mL

Other Acceptable Specimens
Unpreserved urine

Instructions
After urine collection, add 6N HCl to maintain a pH below 3. Urine without preservative is acceptable if pH is below 6 and the sample is shipped frozen. Record patients age on test request form and urine vial.

Transport Temperature
Preserved urine: Room temperature
Unpreserved urine: Frozen

Specimen Stability
Room temperature: 7 days
Refrigerated: 30 days
Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
pH >3.0 • Received unfrozen

Methodology
High Performance Liquid Chromatography (HPLC)

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range
5-HIAA, Random Urine    
2-10 years ≤12.0 mg/g creat
>10 years ≤10.0 mg/g creat
     
Creatinine, Random Urine    
≤6 months 2-32 mg/dL
7-11 months 2-36 mg/dL
1-2 years 2-128 mg/dL
3-8 years 2-149 mg/dL
9-12 years 2-183 mg/dL
>12 years (male) 20-370 mg/dL
>12 years (female) 20-320 mg/dL


Clinical Significance
Values above 10 mg/24 hrs occur in Carcinoid Syndrome. Slight elevations also occur in nontropical sprue and after reserpine administration.
Drugs which can interfere with testing due to physiologic response: Acetaminophen, Alpha and Beta Blockers, Atenolol, Bromocriptine, Broncholdilatirs, Clonidine, Digoxin, Isoniazid, L-Dopa, Labetelol, Methyldopa, Monoamine Oxidase Inhibitors, Nitroglycerin, Sympathomimetic Amines, Phenobarbital, Phenothiazines, Phentolamine, Reserprine, Salicylates, Tricyclic Antidepressants.

Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.