| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Myelin Basic Protein
Test Code663
Preferred Specimen
1.2 mL CSF collected in a sterile CSF collection tube #4
Minimum Volume
0.5 mL
Instructions
CSF must be clear.
Do not centrifuge.
CSF collection tube #4 is preferred. Submitting 4th lumbar puncture collection tube minimizes blood contamination.
Do not centrifuge.
CSF collection tube #4 is preferred. Submitting 4th lumbar puncture collection tube minimizes blood contamination.
Transport Temperature
Frozen
Specimen Stability
Room temperature: 7 days
Refrigerated: 14 days
Frozen: 21 days
Refrigerated: 14 days
Frozen: 21 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis • Xanthochromia/RBCs in CSF
Methodology
Radioimmunoassay (RIA)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Mon, Thurs, Sat; Report available: 3-5 days
Limitations
The pesence of myelin basic protein in the spinal fluid is supportive evidence for the diagnosis of multiple sclerosis and other demyelinating diseases, although it is a non-specific finding and present in other causes of damage to CNS myelin.
Reference Range
| ≤4.0 mcg/L | Negative |
| 4.1-6.0 mcg/L | Weakly positive |
| >6.0 mcg/L | Positive |
Clinical Significance
The concentration of MBP is often increased in patients with demyelinating diseases such as multiple sclerosis and may be increased in patients with head injury, CNS trauma, tumor, stroke, and viral encephalitis.
Performing Laboratory
| Quest Diagnostics Nichols Institute |
| 14225 Newbrook Drive |
| Chantilly, VA 20153 |
