Aldosterone, LC/MS/MS [17181X]

Test Code
53532

Preferred Specimen
1 mL serum collected in a red-top tube (no gel)

Minimum Volume
0.25 mL

Other Acceptable Specimens
Plasma collected in EDTA (royal blue-top), sodium heparin (green-top), lithium heparin (green-top), or EDTA (lavender-top) tube

Instructions
Draw blood in a no-additive (red-top) tube. Separate serum after clotting. Do not submit glass tubes. Draw "upright" samples at least 1/2 hour after patient sits up.

Transport Container
Plastic screw-cap vial

Transport Temperature
Refrigerated (cold Packs)

Specimen Stability
Room temperature: 4 days
Refrigerated: 7 days
Frozen: 28 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Samples collected in serum separator tubes (SST®)

Methodology
Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Limitations
Aldosterone concentration varies based on body position and sodium intake.  24-hour urine specimens for aldosterone are an alternative.

Reference Range
Adult    
Upright 8:00-10:00 A.M. ≤28 ng/dL
Upright 4:00-6:00 P.M. ≤21  ng/dL
Supine 8:00-10:00 A.M. 3-16 ng/dL
Pediatric    
1-12 Months 2-70 ng/dL
1-4 Years 2-37 ng/dL
5-9 Years ≤9 ng/dL
10-13 Years ≤21 ng/dL
14-17 Years ≤35 ng/dL
Infants    
Premature (31-35 Weeks) ≤144 ng/dL
Term ≤217 ng/dL
Tanner Stages    
II-III Males 1-13 ng/dL
II-III Females 2-20 ng/dL
IV-V Males 3-14 ng/dL
IV-V Females 4-32 ng/dL


Clinical Significance
Approximately 1-2% of individuals with primary hypertension have primary hyperaldosteronism characterized by hypokalemia (low potassium) and low direct renin. Because serum aldosterone concentrations vary due to dietary sodium intake and body position, some physicians prefer measurement of 24-hour urine concentration for aldosterone.

Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153




The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.