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Theophylline
MessageSerum half-life is 3 - 11 hours
Performed in the Chemistry Laboratory, x5820
10.2018
Performed in the Chemistry Laboratory, x5820
10.2018
Test Code
THEO
CPT Codes
80198
Preferred Specimen
Plasma from a green top (PST) tube
Minimum Volume
1mL
Instructions
Draw specimen at steady state reached in approximately at 2 - 3 days.
If toxicity is suspected draw anytime during continuous IV or 2 hours after oral dose.
Oral: liquid or immediate release
Trough: collect just prior to next dose
Sustained release: as above or any consistent time within the next dosing interval.
Continuous infusion: ≥ 24 hours after dosage adjustment made during infusion. Post load level, if necessary, ≥ 1 hour after bolus.
Centrifuge within 2 hours of collection
If toxicity is suspected draw anytime during continuous IV or 2 hours after oral dose.
Oral: liquid or immediate release
Trough: collect just prior to next dose
Sustained release: as above or any consistent time within the next dosing interval.
Continuous infusion: ≥ 24 hours after dosage adjustment made during infusion. Post load level, if necessary, ≥ 1 hour after bolus.
Centrifuge within 2 hours of collection
Transport Container
Green Top (PST) tube
Transport Temperature
Room temperature
Specimen Stability
No Add-On
Methodology
Chemiluminescent Microparticle Immunoassay (Abbott Architect i2000)
Setup Schedule
This test is performed 24 hours per day, 7 days per week
Reference Range
Therapeutic range: 10 - 20 ug/mL (Adult)
5 - 10 ug/mL (Neonate)
Critical alert value: ≥ 25 ug/mL
5 - 10 ug/mL (Neonate)
Critical alert value: ≥ 25 ug/mL
Clinical Significance
This test is used to monitor compliance, assess clinical effectiveness, or determine toxicity.
