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Activated Protein C Resistance
Message
Performed in the Hematology Laboratory x5475, 76. Sample MUST be drawn to minimum fill line on tube.
Test Code
APCR
Alias/See Also
APC Resistance
CPT Codes
85307
Preferred Specimen
plasma
Minimum Volume
2.7 mL. Sample MUST be drawn to minimum fill line on tube or the sample will be rejected as QNS.
Instructions
If drawn with other coagulation assays: for up to 3 tests draw 1, 2.7mL sodium citrate tubes. For 4 or more coagulation tests, draw 2, 2.7 mL sodium citrate tubes.
Transport Container
Light Blue Top (Sodium Citrate), 2.7 mL draw tubes
Transport Temperature
Room temperature
Specimen Stability
Refrigerator Stability: 4 hours
Plasma stable up to 6 months at -70° C
Plasma stable up to 6 months at -70° C
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Grossly hemolyzed, QNS, clotted
Methodology
Optical clot detection
Setup Schedule
Performed 2x/week, weekdays between 8-4pm
Limitations
Lupus anticoagulants and anticoagulants such as rivaroxaban, bivalirudin, and apixaban can interfere with this assay.
Reference Range
0-150 YEARS > 2.2.
If the APC is <2.4, there is a reflex to F-V PCR performed in the HLA/Molecular Pathology laboratory.
Clinical Significance
Test for congenital or acquired hypercoagulability; screen for Factor V Leiden.
