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Antithombin III Activitity
MessagePerformed in the Hematology Laboratory x5475, 76.
Sample MUST be drawn to minimum fill line on tube
Sample MUST be drawn to minimum fill line on tube
Test Code
AT
Alias/See Also
AT III
CPT Codes
85300
Preferred Specimen
plasma
Minimum Volume
2.7 mL. Sample MUST be drawn to minimum fill line on tube or the sample will be rejected as QNS.
Instructions
If drawn with other coagulation assays: For up to 3 tests draw 1, 2.7 mL sodium citrate tubes.
For 4 or more coagulation tests, draw 2, 2.7 mL sodium citrate tubes.
For 4 or more coagulation tests, draw 2, 2.7 mL sodium citrate tubes.
Transport Container
Light Blue Top (Sodium Citrate), 2.7 mL draw tube.
Transport Temperature
Room Temperature
Specimen Stability
Refrigerator Stability: 4 hours
Plasma is stable for 6 months frozen at -70° C
Plasma is stable for 6 months frozen at -70° C
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis, QNS, clotted
Methodology
chromogenic
Setup Schedule
Performed 2x /week, weekdays between 8-4 pm.
Limitations
Heparin (UF or LMW) up to 4 U/mL may interfere with assay. The AT value may be low due to the rapid clearance of AT-heparin complexes by the liver. It may be necessary to repeat the test when the patient has been off heparin for at least 7 days.
Reference Range
| 0 - | 5 days | 41% | 93% |
| 41% | 93% | ||
| 5 days - | 1 month | 48% | 108% |
| 48% | 108% | ||
| 1 month - | 3 months | 73% | 121% |
| 73% | 121% | ||
| 3 months - | 6 months | 84% | 124% |
| 84% | 124% | ||
| 6 months - | 150 years | 80% | 130% |
| 80% | 130% | ||
| **Female Ranges are in BLUE | |||
Clinical Significance
A test for congenital or acquired hypercoagulability (pulmonary embolism, stroke, DVT.
AT-III is a heparin co-factor, tested if the patient is non or minimally responsive to unfractionated heparin therapy.
AT-III is a heparin co-factor, tested if the patient is non or minimally responsive to unfractionated heparin therapy.
