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PNH (Paroxysmal Nocturnal Hemoglobinuria) with Flaer

Message
Performed in the Hematology/Flow Cytometry Laboratory  x5479.
Results interpreted by Hematology Pathologist.


Test Code
PNH


CPT Codes
88184, 88185

Preferred Specimen


Whole blood




Minimum Volume
2 mL


Transport Container
3 mL Purple Top (EDTA)


Transport Temperature
Room Temperature


Specimen Stability
24-48 hours refrigerated


Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis (in vitro) QNS, Clotted


Methodology
Flow Cytometry

Setup Schedule
Monday-Friday  9am-7pm


Limitations
Whole blood is the sample of choice for testing. Due to the complexity of myeloid differentiation in the bone marrow,  the interpretation of results may be misleading.


Reference Range


WBC and RBC negative for clone




Clinical Significance


In PNH, since the PIG-1 mutation is present at the stem cell level,  all cell lines may be affected,  showing
reduced or absent expression of glycophosphatidylinositol (GPI)






The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.