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Anticardiolipin Antibodies, IgG and IgM quantitation
MessagePerformed by the Hematology Laboratory x5475, 76
Test Code
ACLAB
Alias/See Also
ACA, cardiolipin antibodies
CPT Codes
86147
Includes
Anticardiolipin IgG and IgM quantitation
Preferred Specimen
Plasma
Minimum Volume
2.7mL sample must be drawnto minimum fill line on tube or the sample will be rejected as QNS.
Instructions
Sample can also be used for B2 Glycoprotein I Antibody quantitation
Transport Container
Blue Top (Sodium Citrate) 2.7 mL draw
Transport Temperature
Room Temperature
Specimen Stability
Room Temperature: 8 hours
Refrigerated: 48 hours
Frozen at -70 degrees: 6 months
Refrigerated: 48 hours
Frozen at -70 degrees: 6 months
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
QNS or Clotted
Methodology
ELISA
Setup Schedule
1x/week, weekdays between 8-4 pm. Sample is frozen until testing is performed.
Limitations
When negative cardiolipin titers are found in the presence of clinical indications, additional testing for lupus
anticoagulants is indicated. Confirmed or active seropositive syphilis patients will have elevated ACA levels. Confirmatory procedures must be performed to rule out syphilis. Anticardiolipin antibodies can occur transiently during infections. Patients testing positive should be retested at a later date. Rheumatoid factor can interfere with the determination of IgM ACA.
anticoagulants is indicated. Confirmed or active seropositive syphilis patients will have elevated ACA levels. Confirmatory procedures must be performed to rule out syphilis. Anticardiolipin antibodies can occur transiently during infections. Patients testing positive should be retested at a later date. Rheumatoid factor can interfere with the determination of IgM ACA.
Reference Range
IgG: 0-15 GPL
IgM: 0-15 MPL
IgM: 0-15 MPL
Clinical Significance
Marker for thrombotic risk or miscarriage
