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Ammonia
Test CodeNH3
CPT Codes
82140
Preferred Specimen
1.0 mL plasma
Transport Container
Lavender Top Tube
Transport Temperature
Place immediately on ice/Frozen
Methodology
Enzymatic
Reference Range
Male: 16-60 umol/L
Female: 11-51 umol/L
Female: 11-51 umol/L
Clinical Significance
Ammonia is generated primarily in the gastrointestinal tract by metabolism of nitrogenous compounds. An excess of ammonia can be toxic to the central nervous system. The Krebs-Henseleit urea cycle provides a means of disposal of ammonia by metabolizing ammonia to urea in the liver.
In adults, elevated ammonia levels can aid in diagnosis of liver failure or hepatic encephalopathy from advanced liver diseases such as viral hepatitis or cirrhosis.