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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Topiramate (Topamax)
Test CodeTOPS
Quest Code
30965
CPT Codes
80201
Preferred Specimen
1 mL serum collected in a red-top tube (no gel), or no additive (royal blue-top) tube, or plasma collected in a lithium heparin (green-top) tube
Minimum Volume
0.5 mL
Other Acceptable Specimens
Plasma collected in a sodium heparin (green-top), or sodium heparin lead-free (tan-top) tube
Instructions
Draw at peak (2-4 hours after dose) or trough (0.5-1 hour before dose) at steady-state.
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 7 days
Refrigerated: 14 days
Frozen: 30 days
Refrigerated: 14 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gel barrier/serum separator tube
Methodology
Chromatography/Mass Spectrometry
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Mon-Sat a.m.; Report available: 2 days
Reference Range
Therapeutic Range
Dose (mg) | Peak (mcg/mL) | Trough (mcg/mL) |
100 | 6.5-9.2 | 4.5-6.6 |
200 | 12.0-16.0 | 8.0-12.0 |
400 | 20.0-30.0 | 14.0-20.0 |
Clinical Significance
Topiramate is an anticonvulsant used as an adjunctive treatment of partial-onset epilepsy. Therapeutic drug monitoring is useful to optimize dose and avoid toxicity.
Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153
Last Updated: January 31, 2020