|
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Intact Parathyroid Hormone
Test CodeIPTH
Alias/See Also
Intact PTH
CPT Codes
83970
Preferred Specimen
Serum
Other Acceptable Specimens
Heparin plasma
Transport Container
Serum Separator Tube (SST)
Plasma Separator Tube (PST)
Plasma Separator Tube (PST)
Transport Temperature
Refrigerated
Specimen Stability
2 Days refrigerated
4 Weeks Frozen
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
No hemolysis
Methodology
Chemiluminescence
Setup Schedule
Mon thru Friday
Reference Range
12.1-72.1 pg/mL
Clinical Significance
- Parathyroid hormone (PTH) is a single chain 84 amino acid polypeptide produced by the parathyroid gland. After PTH is secreted into the blood stream it undergoes extensive proteolysis to generate various fragments. In contrast to its degradation products, the concentration of Intact PTH is relatively independent of glomerular filtration rate and reflects the biologically active portion of the hormone.1 The primary role of PTH is to maintain calcium homeostasis via its interaction with calcitonin. PTH measurement is an important aid in the diagnosis of disorders of calcium metabolism. PTH synthesis and secretion are triggered rapidly by low concentrations of ionized calcium (Ca). The biological activities of PTH are to increase absorption of dietary calcium, decrease renal clearance and mobilize skeletal calcium stores. Abnormally high Ca concentrations suppress secretion of PTH. In conjunction with serum calcium levels, the PTH assay may be used as an aid in the differential diagnosis of hypercalcemia, hypocalcemia and parathyroid disorders. PTH determination is important in monitoring dialysis patients to manage renal osteodystrophy.
Last Updated: April 17, 2019