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Theophylline
Test CodeTHEOS
Quest Code
6311
CPT Codes
80198
Preferred Specimen
1 mL serum collected in a red-top tube (no gel)
Minimum Volume
0.2 mL
Other Acceptable Specimens
Plasma collected in: Sodium heparin (green-top) tube, lithium heparin (green-top) tube, or EDTA (lavender-top) tube
Instructions
Collect as a trough just prior to next dose.
Transport Container
Plastic screw-cap vial
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 6 days
Refrigerated: 7 days
Frozen: 90 days
Refrigerated: 7 days
Frozen: 90 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Serum separator tube (SST)
Methodology
Immunoassay (IA)
Setup Schedule
Set up: Mon-Thurs p.m.; Report available: Next day
Reference Range
≤5 Months | 5.0-10.0 mg/L | |
>5 Months | 10.0-20.0 mg/L |
Clinical Significance
Theophylline is used in the treatment of bronchial asthma as well as in the treatment of chronic obstructive pulmonary disease and episodes of prolonged apnea in pre-term infants. Theophylline levels are monitored to assure adequate therapeutic levels are achieved and to avoid toxicity.
Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153
Last Updated: November 5, 2013