ANCA Screen with MPO and PR3, with Reflex to ANCA Titer

Message

SRHC Clients:

1 red top tube
Do not use gel barrier tubes
Transport to SRHC laboratory within 8 hours

Test Code

LAB7050

Quest Code

70159

Alias/See Also

ANCA Inflammatory Bowel Disease
EPIC: LAB7050

CPT Codes
86021 (x2), 86036

Includes

ANCA Screen with Reflex to ANCA Titer, Myeloperoxidase Ab (MPO), Proteinase-3 Antibody
If ANCA Screen is positive, C-ANCA Titer and/or P-ANCA Titer and/or atypical P-ANCA Titer will be performed at an additional charge (CPT code(s): 86021 for each titer performed) .

Preferred Specimen

2 mL serum (1.5 mL minimum)

Minimum Volume

0.8 mL

Transport Temperature

Refrigerate, stable 7 days

Specimen Stability

Room temperature: 7 days
Refrigerated: 14 days
Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Gross hemolysis • Grossly lipemic

Methodology
Immunoassay (IA)

Setup Schedule

Set up: Mon-Sat; Report available: 3-5 days

Reference Range

ANCA Screen	Negative
P-ANCA Titer	<1:20
C-ANCA Titer	<1:20
Atypical P-ANCA Titer	<1:20

Myeloperoxidase Antibody

<1.0 AI	No antibody detected
≥1.0 AI	Antibody detected

Proteinase-3 Antibody

<1.0 AI	No antibody detected
≥1.0 AI	Antibody detected

Clinical Significance

Testing for anti-neutrophil cytoplasmic antibodies (P-ANCA and/or C-ANCA) has been found to be useful in establishing the diagnosis of suspected vascular diseases, inflammatory bowel disease, as well as other autoimmune diseases.

Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.