Creatinine Clearance

Test Code

7943

CPT Codes
82575

Includes

Creatinine (serum and urine)
eGFR
Creatinine Clearance (calculation)

CPT code 81050 may be added at an additional charge for volume measurement

Preferred Specimen

10 mL aliquot from a well-mixed, 24-hour urine collection - no preservative
and 1 mL serum

Minimum Volume

0.5 mL urine • 0.5 mL serum

Other Acceptable Specimens

Acidified urine • Urinalysis transport tube (yellow-top, blue fill line, preservative tube) • Serum collected in: Spun serum separator tube (SST) • Plasma collected in: Sodium heparin (green-top) tube or lithium heparin (green-top) tube

Instructions

Record total volume and collection duration on specimen container and test requisition. Indicate the patient's height (in feet and inches) and weight (in lbs.) on test requisition.
Note: A serum creatinine level must be collected within 24 hours of the beginning or ending of the urine collection.

Transport Container

Urine: Plastic screw-cap container
Serum: Transport tube

Transport Temperature

Room temperature

Specimen Stability

⁠⁠⁠⁠⁠⁠⁠Serum and urine
Room temperature: 7 days
Refrigerated: 7 days
Frozen: 28 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Grossly icteric serum

Methodology
Spectrophotometry (SP)

Reference Range

Creatinine
Age	Male (mg/dL)	Female (mg/dL)
≤2 days	0.79-1.58	0.79-1.58
3-27 days	0.35-1.23	0.35-1.23
1 month-9 years	0.20-0.73	0.20-0.73
10-12 years	0.30-0.78	0.30-0.78
13-15 years	0.40-1.05	0.40-1.00
16-17 years	0.60-1.20	0.50-1.00
18-29 years	0.60-1.24	0.50-0.96
30-39 years	0.60-1.26	0.50-0.97
40-49 years	0.60-1.29	0.50-0.99
50-59 years	0.70-1.30	0.50-1.03
60-69 years	0.70-1.35	0.50-1.05
70-79 years	0.70-1.28	0.60-1.00
≥80 years	0.70-1.22	0.60-0.95

For patients >49 years of age, the upper reference limit for creatinine is approximately 13% higher for people identified as African-American.
⁠⁠⁠⁠⁠⁠⁠

eGFR

≥60 mL/min/1.73m²

Creatinine, 24-Hour Urine
<3 Years	Not established
3-8 Years	0.10-0.80 g/24 h
9-12 Years	0.20-1.40 g/24 h
13-17 Years	0.40-1.90 g/24 h
>17 Years	0.50-2.15 g/24 h

Creatinine Clearance, Urine
Male	85-125 mL/min
Female	75-115 mL/min

Clinical Significance

Creatinine Clearance is used to evaluate the glomerular filtration rate (GFR). Clearance is defined as that volume of plasma from which a measured amount of substance could be completely eliminated into the urine per unit of time. Daily creatinine production is fairly constant except when there is massive injury to muscle.

Last Updated: November 6, 2024

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.