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Cryoglobulin, Qualitative Analysis
Test Code383
CPT Codes
82595
Preferred Specimen
3 mL fasting serum collected in a red-top tube (no gel)
Patient Preparation
Overnight fasting is required
Minimum Volume
2 mL
Instructions
Allow blood to clot for one (1) hour in a 37° C water bath, incubator, heat block, or heel warmer. After clotting, centrifuge the specimen as quickly as possible. It is not necessary to use a warm centrifuge but do not use a refrigerated one. Decant all of the serum into one screw-cap vial (do not aliquot any of the cryoglobulin serum into any other tube). Transport at room temperature.
Note: If the sample is not kept at 37° C during clotting, the cryoglobulin, if present, can precipitate during centrifugation and be lost in the clot resulting in a false negative result.
Transport Container
Transport tube
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 14 days
Refrigerated: 14 days
Frozen: 30 days
Refrigerated: 14 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Grossly lipemic • Received refrigerated • Received frozen • Icteric samples • Serum separator tube (SST)
Methodology
Visual Inspection
Setup Schedule
Set up: Daily; Report available: 5-7 days
Clinical Significance
Cryoglobulins are a group of proteins which precipitate from serum, plasma or urine upon exposure to cold.
Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153
Last Updated: November 6, 2024
