Complement Component C3c and C4c

Test Code

5704

CPT Codes
86160 (x2)

Preferred Specimen

1 mL serum

Minimum Volume

0.5 mL

Transport Container

Transport tube

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: Unacceptable
Refrigerated: 8 days
Frozen: 8 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

CSF • Plasma

Methodology
Immunoturbidimetric

Setup Schedule

Sun-Fri

Report Available

3-6 days

Reference Range

See individual tests

Clinical Significance

Decreased concentrations of both C3 and C4 suggest activation of the classical pathway, whereas decreased concentration of just C3 suggests activation of the alternative pathway. Both complement factors may be used to monitor activity of patients with systemic lupus erythematosus (SLE) and immune complex-induced vasculitis.

Performing Laboratory

Quest Diagnostics Nichols Institute-San Juan Capistrano, CA

33608 Ortega Highway

San Juan Capistrano, CA 92675-2042

Last Updated: November 6, 2024

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.