CD21, IHC without Interpretation

40016

Formalin-fixed paraffin embedded tissue

Fixed tissue • Five 4-micron unstained slides

Do not place paper labels with adhesive backing on slides. Use pencil or xylene resistant pen to write on the frosted end of the slide only.

Pathology report is required

IHC specimen transport kit

Room temperature

Room temperature: Indefinite
Refrigerated: Indefinite
Frozen: Unacceptable

Received frozen • Tissue in formalin

Mon-sat

1-2 days

CD21 antigen is a type I integral membrane glycoprotein of molecular weight 140 kD, which functions as the receptor for the C3d fragment of the third complement component. The CD21 molecule, present on mature B cells, is involved in transmitting growth-promoting signals to the interior of the B cell and acts as a receptor for Epstein-Barr virus. CD21 antigen is reported to be found in B cell chronic lymphocytic leukemias and in a subset of T cell acute lymphocytic leukemias, but is absent on T lymphocytes, monocytes and granulocytes. CD21 antigen is also reported to be expressed in follicular dendritic cells and in follicular and centrocytic lymphomas, mature leukemias and lymphomas and at high density in follicular dendretic cells.