CAH Panel 1 (21-Hydroxylase vs 11Beta-Hydroxylase Deficiency)

Test Code

15269

CPT Codes
82157, 82533, 82634, 83498, 84403

Includes

11-Deoxycortisol
Cortisol, Total, LC/MS
17-Hydroxyprogesterone
Androstenedione
Testosterone, Total, MS

Preferred Specimen

3 mL serum collected in a red-top tube (no gel)

Minimum Volume

0.6 mL

Instructions

An early morning specimen is preferred. Specify time of day specimen was collected, patient age and sex on test requisition.

Transport Container

Transport tube

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 48 hours
Refrigerated: 7 days
Frozen: 28 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Gross hemolysis • Grossly lipemic • Serum separator tube (SST)

Methodology

Chromatography/Mass Spectrometry

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range

See individual tests

Clinical Significance

Deficiency of 21-Hydroxylase is the most frequent cause of congenital adrenal hyperplasia (accounting for ~95% of cases) and 11Beta-Hydroxylase is the second most frequent (~5% of cases). Deficiencies of these two enzymes result in the accumulation of distinct steroid precursors.

Performing Laboratory

Quest Diagnostics Nichols Institute-San Juan Capistrano, CA

33608 Ortega Highway

San Juan Capistrano, CA 92675-2042

Last Updated: November 6, 2024

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.