CAH Panel 6 (StAR Deficiency)

Test Code

15276

CPT Codes
82088,82533,82626,84140

Includes

Cortisol, Total, LC/MS
Pregnenolone, LC/MS
DHEA (Dehydroepiandrosterone) Unconjugated
Aldosterone, LC/MS

Preferred Specimen

4 mL serum collected in a red-top tube (no gel)

Patient Preparation
Overnight fasting is preferred

Minimum Volume

1.6 mL

Instructions

Collect blood in a Vacutainer® with no additives. Allow blood to clot (30 minutes) at room temperature, 18-25°C. Centrifuge and separate the serum from the cells. Freeze as soon as possible.
Specify age and sex on test request form. Immediately put sample on ice after collection.

Transport Container

Transport tube

Transport Temperature

Frozen

Specimen Stability

Room temperature: Unacceptable
Refrigerated: 72 hours
Frozen -20° C: 14 days
Frozen -70° C: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Moderate to gross hemolysis • Serum separator tube (SST) • Plasma

Methodology
Chromatography/Mass Spectrometry

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range

See Laboratory Report

Clinical Significance

Steroidogenic acute regulatory protein (StAR) catalyzes the initial rate-limiting in the formation of steroid hormones. Affected individuals present with deficiency of cortisol and aldosterone, as well as early precursors in the synthesis of steroid hormones (Pregnenalone; DHEA (Dehydroepiandrosterone). Additional testing may be required to establish a diagnosis.

Performing Laboratory

Quest Diagnostics Nichols Institute-San Juan Capistrano, CA

33608 Ortega Highway

San Juan Capistrano, CA 92675-2042

Last Updated: November 6, 2024

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.