Cyclin D1 (BCL 1), IHC with Interpretation

Test Code

15474

CPT Codes
88342

Preferred Specimen

Formalin-fixed, paraffin embedded tissue block

Other Acceptable Specimens

Tissue in neutral buffered formalin • Fresh (unfixed) tissue • Decalcified • Bouin's • Zinkers • Tissue in alcohol

Instructions

Do not freeze

Transport Container

Paraffin block bag

Transport Temperature

Room temperature

Specimen Stability

Room temperature: Indefinite
Refrigerated: Indefinite
Frozen: Not established

Methodology
Immunohistochemical Assay (IHC)

Setup Schedule

Mon-sat

Report Available

2-3 days

Clinical Significance

Approximately 65% of mantle cell lymphomas (MCL) are characterized by a t (11; 14) (q13; Q32) gene translocation that causes deregulation of the expression of the BCL-1 gene. This abnormality in turn leads to deregulation of Cyclin D1. Detection of Cyclin D1 is useful in detecting disease.

Performing Laboratory

Quest Diagnostics Nichols Institute-San Juan Capistrano, CA

33608 Ortega Highway

San Juan Capistrano, CA 92675-2042

Last Updated: November 6, 2024

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.