Cutaneous Direct Immunofluorescence

Test Code

18899

CPT Codes
88346, 88350 (x5)

Includes

IgG, IgA, IgM, C3, C5b-9, Fibrinogen

Preferred Specimen

Standard skin biopsy, 4 mm in size, submitted in Michel's fixative (in supplied vial)

Minimum Volume

1 mm

Other Acceptable Specimens

Standard skin biopsy, 4 mm in size, submitted in zeus fixative

Transport Container

Michel's fixative

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 21 days
Refrigerated: 21 days
Frozen: Unacceptable

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Received frozen

Methodology
Immunoassay (IA)

Setup Schedule

Mon-Fri

Reference Range

See Laboratory Report

Clinical Significance

These studies contribute to the diagnosis of autoimmune blistering diseases, dermatitis herpetiformis, and IgA vasculitis. Important in the evaluation of other autoimmune and inflammatory skin diseases including non-IgA vasculitides and interface and lichenoid dermatitis/mucositis such as connective tissue disorders, lichen planus, etc. The panel includes the C5b-9 antibody to better distinguish between some forms of Lupus and Dermatomyocitis. Its presence or absence is also critical in the evaluation of other types of connective tissue diseases and many vasculitides.

Performing Laboratory
Dermpath Diagnostics South Florida
895 Southwest 30th Avenue, Suite 101
Pompano Beach, FL 33069-4887

Last Updated: November 6, 2024

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.