Catecholamines, Total, Suppression by Clonidine, Plasma

Test Code

10068

CPT Codes
82383 (x4)

Includes

Catecholamines, Total, Baseline
Catecholamines, Total, 1-hour
Catecholamines, Total, 2-hours
Catecholamines, Total, 3-hours

Preferred Specimen

2 mL frozen plasma collected in a sodium heparin (green-top) tube - each specimen

Patient Preparation
Patients should be resting supine for 1 hour in a non-stressful environment. An indwelling catheter should be placed 30 min before collection of the baseline sample.

Minimum Volume

1 mL each specimen

Other Acceptable Specimens

EDTA (lavender-top) tube

Instructions

Collect baseline sample before administration of clonidine (0.3 mg per 70 kg body weight). Collect samples at 1, 2 and 3 hours using indwelling catheter.

Note: Indwelling catheter should be placed 30 min before collection of the baseline sample.

Transport Container

Transport tube (x4)

Transport Temperature

Frozen

Specimen Stability

Room temperature: 6 hours
Refrigerated: 6 hours
Frozen: 31 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Moderate or gross hemolysis

Methodology
Liquid Chromatography/Mass Spectrometry (LC/MS)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range

Catecholamines, Total, Plasma

Baseline	<18 years	No Reference Range Available
Baseline	≥18 years	Supine: <632 pg/mL Upright: <1046 pg/mL
1 Hour		Not Established
2 Hours		Not Established
3 Hours		Not Established

Clinical Significance

Catecholamines include the hormones epinephrine, norepinephrine, and dopamine. Catecholamines, along with VMA, are produced in chromaffin cell tumors, pheochromocytoma, ganglioneuroma, and neuroblastoma. Symptoms of pheochromocytomas include episodic hypertension, headaches, sweating, heart palpitations, and anxiety.

Performing Laboratory

Quest Diagnostics Nichols Institute-San Juan Capistrano, CA

33608 Ortega Highway

San Juan Capistrano, CA 92675-2042

Last Updated: November 6, 2024

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.