Levetiracetam Level

Test Code

LEVET

Alias/See Also

Keppra Level

Preferred Specimen

1 ml serum from Plain red top tube.

Minimum Volume

0.5 mL

Instructions

Draw specimen immediately before next scheduled dose or for sustained released formulations draw blood at least 12 hours after last dose.

Transport Container

Plastic vial

Transport Temperature

Ambient temperature

Specimen Stability

14 days ambient temperature

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Gross hemolysis, gross lipemia, gross icterus

Report Available

2-4 days

Reference Range

12.0-46.0 mcg/mL

Clinical Significance

Given the lack of drug interactions and favorably pharmacokinetics, the primary uses for therapeutic drug monitoring of levetiracetam are compliance assurance and management of physiological changes such as puberty, pregnancy, and aging. Toxicities associated with levetiracetam use include decreased hematocrit and red blood cell count, decreased neutrophil count, somnolence, asthenia, and dizziness. These toxicities may be associated with blood concentrations in the therapeutic range.

Performed By
Quest Diagnostics DEMO

Last Updated: April 14, 2017

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.