Coagulation Consult, Thrombosis/Hypercoagulability

HYPER

Hypercoagulabilty Consult

6 mL platelet poor sodium citrate plasma in 6 vials contianing 1 mL each AND 6 mL ACD whole blood

5 mL platelet poor sodium citrate plasma in 5 vials contianing 1 mL each AND 3 mL ACD whole blood

EDTA whole blood is an acceptable substitute for the ACD prtion of the required specimen

Submission of platelet poor plasma is critical to accurate results. Contact laboratory for further information.

Frozen for plasma aliquots and ambient for whole blood tube

7 days at respective temperatures

Gross hemolysis, gross lipemia, gross icterus

7-10 days

An interpretive report will be provided.

Thrombophilia is defined as an acquired or familial disorder associated with thrombosis. The clinical presentation of an underlying thrombophilia may include venous thromboembolism (deep vein thrombosis, pulmonary embolism, superficial vein thrombosis), recurrent miscarriage, and complications of pregnancy (eg, severe preeclampsia, abruptio placentae, intrauterine growth restriction, stillbirth). Other possible clinical presentation includes arterial thrombosis (especially among patients <50 years of age with no other risk factors for atherosclerotic arterial occlusive disease (diabetes mellitus, hypercholesterolemia, hypertension, or tobacco smoking) and aseptic necrosis of bone (eg, femoral head mandible). Demographic or environmental exposures that compound the risk of venous thromboembolism among persons with a thrombophilia include increasing age, male gender, obesity, surgery, trauma, hospitalization for medical illness, malignant neoplasm, prolonged immobility during travel (eg, prolonged airplane travel), oral contraceptive use, estrogen therapy (both oral and transdermal), tamoxifen and raloxifene therapy, and infertility drugs.