Zinc Protoporphyrin (ZPP)

Test Code

948

CPT Codes
84202

Preferred Specimen

2 mL whole blood collected in an EDTA (royal blue-top) tube

Minimum Volume

0.5 mL • Pediatric specimen: 0.2 mL

Other Acceptable Specimens

Whole blood collected in: Sodium heparin (royal blue-top) tube, sodium heparin (green-top) tube, lithium heparin (green-top) tube or K2 EDTA (tan-top) tube

Instructions

Use a lead-free tube if blood lead is also requested

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 4 days
Refrigerated: 10 days
Frozen: Unacceptable

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Hemolysis • Received frozen • Clotted • EDTA (lavender-top) tube

Methodology
Hematofluorometry

Setup Schedule

Set up: Mon-Sat; Report available: 1-2 days

Limitations

Aluminum and anemia of chronic disease may cause elevated results.

Clinical Significance

Zinc protoporphyrin (ZPP) accumulates in erythrocytes as a result of chronic lead absorption or iron deficiency anemia.

Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153

Last Updated: October 15, 2025

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.