SurePath™ Pap and HPV mRNA E6/E7 Reflex Genotypes 16, 18/45

Test Code

16306

CPT Codes
87624, 88142<br>This test is not available for California patient testing.

Includes

SurePath™ Pap
HPV mRNA E6/E7 with Reflex to HPV Genotypes 16, 18/45

Pap results requiring physician interpretation will be performed at an additional charge (CPT Code(s): 88141; HCPCS: G0124).
If the Pap is normal and the HPV mRNA E6/E7 is detected, then HPV Genotypes 16, 18/45 will be performed at an additional charge (CPT Code(s): 87625).

Preferred Specimen

Pap sample collected in 1 SurePath™ pap vial

Minimum Volume

1 SurePath pap vial

Instructions

For instructions refer to
//www.questdiagnostics.com/dms/Documents/Other/Specimen_Collection_and_Transport_Guide_2019.pdf

Transport Container

1 SurePath pap vial

Transport Temperature

Room temperature

Specimen Stability

SurePath Pap
Room temperature: 28 days
Refrigerated: 6 months
Frozen: Unacceptable

SurePath HPV
Room temperature: 7 days
Refrigerated: 7 days
Frozen: Unacceptable

SurePath Preservative in Aptima Transfer Tube
Room temperature: 7 days
Refrigerated: 7 days
Frozen: Unacceptable

Refer to local service area for specimen retention

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

SurePath™ vials without the head of the collection device(s) in the fluid • Swabs • SurePath vials received frozen • Cervical swabs in Digene® HC cervical sampler • Digene vials

Methodology

Liquid Based-density Gradient Sedimentation • Transcription-Mediated Amplification (TMA)

Setup Schedule

Set up: Mon-Sat; Report available: 5 days

Reference Range

See Laboratory Report

Clinical Significance

The combination of tests will assist in triaging patients over age 30 who have a normal pap and a positive HPV. This combination of results automatically adds a molecular genotyping assay that detects HPV 16 and 18. The genotype results assist in determining which women should be referred for colposcopy.
This assay detects E6/E7 viral messenger RNA (mRNA) from 14 high-risk HPV types (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68).

Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153

Last Updated: May 19, 2016

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.