Coccidioides Antibody, Complement Fixation, CSF [5295X]

Test Code

52958

Alias/See Also

1230120119 | LAB1885: Coccidioides Ab, Complement Fixation, CSF | QUEST EAP: 52958

CPT Codes
86317

Preferred Specimen

1 mL CSF collected in a sterile, plastic leak-proof CSF container

Minimum Volume

0.2 mL

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 7 days
Refrigerated: 14 days
Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Gross hemolysis • Grossly icteric

Methodology
Complement Fixation (CF)

Setup Schedule

Set up: Mon, Wed, Fri, Sat; Report available: 3-6 days

Limitations

False-negatives may occur in patients with solitary pulmonary lesions. Patients with active histoplasmosis may generate cross reactions. Elevated serum antibodies may be present in patients with meningeal coccidiocomycosis.

Reference Range

<1:1 titer

Interpretive Criteria

<1:1	Antibody Not Detected
≥1:1	Antibody Detected

Clinical Significance

Infection by Coccidioides immitis can produce a spectrum of disease with most patients being asymptomatic and some developing disseminated disease including pneumonia and meningitis. C. immitis meningitis is associated with a mononuclear pleocytosis.

Performing Laboratory

Quest Diagnostics Nichols Institute

14225 Newbrook Drive

Chantilly, VA 20153

Last Updated: April 21, 2023

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.