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Bile Acids, Total , Enzymatic
Test Code14801
Preferred Specimen
1 mL serum
Patient Preparation
Fast for 8 hours
Minimum Volume
0.5 mL
Instructions
Centrifuge serum samples within 1 hour of collection and transfer serum into sterile transport tube(s).
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: Unacceptable
Refrigerated: 7 days
Frozen: 30 days
Refrigerated: 7 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received Room Temperature • Unspun serum separator tube • Red top tube (no gel)
Methodology
Enzymatic
Setup Schedule
Set up: Mon-Sat; Report available: 1-2 days
Clinical Significance
Total bile acids are metabolized in the liver and, hence, serve as a marker for normal liver function. Serum total bile acids are increased in patients with acute hepatitis, chronic hepatitis, liver sclerosis and liver cancer.
Used to screen pregnant women for obstetric cholestasis. Symptoms of cholestasis included persistent itching in the third trimester of pregnancy and possible risks of unborn baby including stillbirth, premature labor and bleeding. The frequency of obstetric cholestasis varies and is 1 in 100 in pregnant European women vs. 1 in 10 in South American women. Total bile acids levels are the most sensitive indicator for monitoring the effectiveness of interferon treatment of chronic hepatitis C patients.
Used to screen pregnant women for obstetric cholestasis. Symptoms of cholestasis included persistent itching in the third trimester of pregnancy and possible risks of unborn baby including stillbirth, premature labor and bleeding. The frequency of obstetric cholestasis varies and is 1 in 100 in pregnant European women vs. 1 in 10 in South American women. Total bile acids levels are the most sensitive indicator for monitoring the effectiveness of interferon treatment of chronic hepatitis C patients.
