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Autoimmune Cerebellar Ataxia Panel
Test Code90133
Includes
Yo Antibody Screen with Reflex to Titer and Western Blot
Voltage-Gated Calcium Channel (VGCC) Type P/Q Antibody
Tissue Transglutaminase (tTG) Antibody (IgA)
IgA (Immunoglobulin A)
If Yo Antibody, IFA, Serum is positive, then Yo Antibody, Western Blot, Serum will be performed at an additional charge (CPT code(s): 84181).
If Yo Antibody, Western Blot, Serum is positive, then Yo Antibody, Titer, Serum will be performed at an additional charge (CPT code(s): 86256).
If Tissue Transglutaminase (tTG) Antibody (IgA) is detected (≥15.0 U/mL), then Endomysial Antibody (IgA) Screen with Reflex to Titer will be performed at an additional charge (CPT code(s): 86231).
If Endomysial Antibody Screen (IgA) is positive, then Endomysial Antibody Titer will be performed at an additional charge (CPT code(s): 86231).
If IgA, Serum is abnormal, then tTG (IgG) will be performed at an additional charge (CPT code(s): 86364).
Voltage-Gated Calcium Channel (VGCC) Type P/Q Antibody
Tissue Transglutaminase (tTG) Antibody (IgA)
IgA (Immunoglobulin A)
If Yo Antibody, IFA, Serum is positive, then Yo Antibody, Western Blot, Serum will be performed at an additional charge (CPT code(s): 84181).
If Yo Antibody, Western Blot, Serum is positive, then Yo Antibody, Titer, Serum will be performed at an additional charge (CPT code(s): 86256).
If Tissue Transglutaminase (tTG) Antibody (IgA) is detected (≥15.0 U/mL), then Endomysial Antibody (IgA) Screen with Reflex to Titer will be performed at an additional charge (CPT code(s): 86231).
If Endomysial Antibody Screen (IgA) is positive, then Endomysial Antibody Titer will be performed at an additional charge (CPT code(s): 86231).
If IgA, Serum is abnormal, then tTG (IgG) will be performed at an additional charge (CPT code(s): 86364).
Preferred Specimen
3 mL serum
Patient Preparation
Overnight fasting is preferred
Minimum Volume
1.3 mL
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 48 hours
Refrigerated: 7 days
Frozen: 21 days
Refrigerated: 7 days
Frozen: 21 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
See individual assays
Methodology
Immunoassay (IA) • Immunofluorescence Assay (IFA) • Immunoturbidometry • Radiobinding Assay (RBA)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
See individual assays
Clinical Significance
Cerebellar ataxia may occur as a result of autoantibodies to cerebellar targets. These may include antibodies to the Purkinje cell antigen Yo, the voltage gated calcium channel (VGCC) or tissue transglutaminase (tTG). Glutin ataxia is associated with widespread tissue transglutaminase (tTG) IgA deposition around vessels in the cerebellum, pons, and medulla.
