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Thyroid Peroxidase and Thyroglobulin Antibodies
Test Code7260
Preferred Specimen
1 mL serum
Patient Preparation
Dietary supplements containing biotin may interfere in assays and may skew results to be either falsely high or falsely low. For patients receiving the recommended daily doses of biotin, draw samples at least 8 hours following the last biotin supplementation. For patients on mega-doses of biotin supplements, draw samples at least 72 hours following the last biotin supplementation.
Minimum Volume
0.6 mL
Instructions
Administration of STRENSIQ may interfere in certain assays and may falsely elevate values. For patients receiving STRENSIQ, consideration should be given to using alternate methods.
Transport Temperature
Room Temperature
Specimen Stability
Room temperature: 7 days
Refrigerated: 7 days
Frozen: 28 days
Refrigerated: 7 days
Frozen: 28 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Grossly lipemic
Methodology
Immunoassay (IA)
Setup Schedule
See individual assays
Clinical Significance
Most patients with thyroid autoimmune disease have Thyroglobulin Antibody. The antiperoxidase antibody (anti-TPO) provides additional specificity. Approximately 95% of patients with diffuse goiter, hypothyroidism, or both have Anti-PTO. Anti-PTO is especially useful with patients with subclinical hypothyroidism (elevated TSH and normal free T4 concentrations). Many of these patients will develop hypothyroidism.
