Tricyclic Antidepressant Detection

Test Code

3542

Preferred Specimen

One 5 mL plain red. EDTA acceptable.

Minimum Volume

1 mL serum at 2-8°C. (Min: 0.5 mL) Submit specimen in orignal tube.

Transport Temperature

1 mL serum at 2-8°C. (Min: 0.5 mL) Submit specimen in orignal tube.

Specimen Stability

After separation from cells: Ambient: 2 days; Refrigerated: 2 days; Frozen: 2 months

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Separator tubes.

Methodology
Enzyme Immunoassay

Setup Schedule

Sun-Sat

Report Available

Within 24 hours

Limitations

Separate serum from cells ASAP.

Clinical Significance

This result represents the total level of all detectable tricyclic antidepressants present. Tricyclic antidepressants detectable with this assay include: amitriptyline, clomipramine, desipramine, doxepin, imipramine, nortriptyline, protriptyline, and trimipramine.Levels of tricyclic antidepressants in the therapeutic range may not be detectable. False-positive results may occur with the following drugs: Seroquel® (quetiapine fumarate), Trileptal® (oxcarbazepine), Benadryl® (diphenhydramine) at toxic concentrations, Flexeril (cyclobenzaprine), Thioridazine, and Thorazine® (chlorpromazine).

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.