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B-Type Natriuretic Peptide
Test Code2676
Alias/See Also
BNPEP; BN PEP; Brain Type Natriuretic Peptide; BNP
Preferred Specimen
One 3 mL lavender (EDTA) or pink (K2EDTA).
Minimum Volume
2 mL plasma, frozen. (Min: 0.5 mL) Submit specimen in an ARUP Standard Transport Tube.
Transport Temperature
2 mL plasma, frozen. (Min: 0.5 mL) Submit specimen in an ARUP Standard Transport Tube.
Specimen Stability
After separation from cells: Ambient: 4 hours; Refrigerated: 4 hours; Frozen: 4 months
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolyzed specimens collected in non-EDTA tubes. Specimens frozen in separator tube. Frozen whole blood. Specimen exposed to repeated freeze/thaw cycles. Ambient or refrigerated specimens more than 4 hours old.
Methodology
Chemiluminescent Immunoassay
Setup Schedule
Sun-Sat
Report Available
Within 24 hours
Limitations
Separate plasma from cells ASAP. Freeze plasma within four hours of collection.
Clinical Significance
A cutoff of 100 pg/mL has been demonstrated to provide the maximal combination of sensitivity, specificity, and negative predictive value for contributing to the diagnosis of congestive heart failure (CHF). A BNP value greater than 100 pg/mL is consistent with a diagnosis of CHF in the appropriate clinical setting. False-positive results are more common in females greater than 75 years of age. Blood concentrations of natriuretic peptides may also be elevated in patients with myocardial infarction and in patients who are candidates for or are undergoing renal dialysis.
