A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #

INTERLEUKIN 28B 

Test Code
IL28Q


Quest Code
90251


Alias/See Also
LAB2248  INTERLEUKIN 28B POLYMORPHISM GENOTYPE


CPT Codes
81283<br /> This test is for non-New York patient testing. For New York testing, please see Test Code 90252.

Preferred Specimen
5 mL whole blood collected in an EDTA (lavender-top) tube


Patient Preparation
Do not eat immediately prior to sample collection. If patient has eaten recently, rinse mouth with plain water.

Minimum Volume
2 mL


Other Acceptable Specimens
Whole blood collected in: ACD solution A (yellow-top) tube •  ACD solution B (yellow-top) tube. Do not freeze blood.
 


Instructions
Do not freeze whole blood.

Buccal Swab: Use only Celera/Copan DNA Collection Kit (Celera part # is 5002737) or DNA Genotek OraCollect Kit (OC-100). Follow collection kit instructions.


Transport Temperature
Room temperature


Specimen Stability
Whole blood
Room temperature: 8 days
Refrigerated: 8 days
Frozen: Unacceptabl e


Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received frozen


Methodology
Real-Time Polymerase Chain Reaction

Setup Schedule
Set up: Daily night; Report available: 3 days


Reference Range
See Laboratory Report


Clinical Significance
The C polymorphism in rs12979860 is strongly associated with a two fold greater sustained virological response in European, African American, and Hispanic populations. Knowledge of the host genotype of patients infected with HCV will aid in the clinical decision to initiate treatment with PegIFN and RBV (a 48 week course of interferon and ribavirin which has limited efficacy and is often poorly tolerated due to side effects that prevent patients from finishing treatment).


Performing Laboratory
Quest Diagnostics Nichols Institute-San Juan Capistrano, CA
33608 Ortega Highway
San Juan Capistrano, CA 92675-2042




The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.