p27, IHC with Interpretation

Test Code

90176

CPT Codes
88342

Preferred Specimen

Formalin-fixed, paraffin-embedded tissue block

Other Acceptable Specimens

Minimum: 3 unstained, positively charged slides

Instructions

Please include surgical pathology report.

Transport Container

IHC Specimen Transport Kit

Transport Temperature

Room temperature

Specimen Stability

Room temperature: Indefinitely
Refrigerated: Indefinitely
Frozen: Unacceptable

Methodology
Immunohistochemistry

Setup Schedule

Set up: Mon-Fri a.m.; Report available: 3 days

Reference Range

Interpretive report

Clinical Significance

Dysregulation of the nuclear cycle regulator p27 is implicated in the development and progression of oral squamous cell carcinoma (including by HPV). Underexpression of p27 is an adverse prognostic marker in breast, lung, prostate, and thyroid carcinomas. It is also deleted/underexpressed in some high-grade hematopoietic tumors.

Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.