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ZAP70, IHC with Interpretation
Test Code90192
CPT Codes
88342
Preferred Specimen
Formalin-fixed, paraffin-embedded tissue block
Other Acceptable Specimens
Minimum: 3 unstained, positively charged slides
Instructions
Please include surgical pathology report.
Transport Container
IHC Specimen Transport Kit
Transport Temperature
Room temperature
Specimen Stability
Room temperature: Indefinitely
Refrigerated: Indefinitely
Frozen: Unacceptable
Refrigerated: Indefinitely
Frozen: Unacceptable
Methodology
Immunohistochemistry
Setup Schedule
Set up: Mon-Fri a.m.; Report available: 3 days
Reference Range
Interpretive report
Clinical Significance
The T-cell kinase ZAP70 is anomalously expressed in the more aggressive, pre-germinal center subset of B-cell chronic lymphocytic leukemia and small lymphocytic lymphoma. Expression of ZAP70 by immunohistochemistry is well-correlated with overexpression of ZAP70 by transcript analysis or immunohistochemistry.
Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153