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Mayo #8271 Serum Ig Index (IgG/Albumin Ratio, Spinal Fluid)
Test Code8271
Alias/See Also
"Albumin Ratio
IgG/Albumin Ratio, CSF
Specific Protein (CSF)
"
IgG/Albumin Ratio, CSF
Specific Protein (CSF)
"
CPT Codes
82042, 82784
Preferred Specimen
CSF
Minimum Volume
0.5 mL
Transport Container
Sterile vial
Specimen Stability
"Refrigerated (preferred) 14 days
Ambient 14 days
Frozen 14 days
"
Ambient 14 days
Frozen 14 days
"
Methodology
Nephelometry
Setup Schedule
Monday through Saturday; 2 p.m.
Report Available
1-2 days specimen retained for 2 weeks
Reference Range
"CSF IgG: 0.0-8.1 mg/dL
CSF albumin: 0.0-27.0 mg/dL
CSF IgG/albumin: 0.00-0.21
"
CSF albumin: 0.0-27.0 mg/dL
CSF IgG/albumin: 0.00-0.21
"
Clinical Significance
"The cerebrospinal fluid (CSF) index is useful in the diagnosis of individuals with multiple sclerosis. In the absence of a paired CSF and serum specimen, the CSF IgG/albumin ratio can be assessed.
The index is independent of the activity of the demyelinating process.
Elevation of IgG levels in the cerebrospinal fluid (CSF) of patients with inflammatory diseases of the central nervous system (CNS) (multiple sclerosis, neurosyphilis, acute inflammatory polyradiculoneuropathy, subacute sclerosing panencephalitis) is due to local (CNS) synthesis of IgG.
The two most commonly used diagnostic laboratory tests for multiple sclerosis are CSF index and oligoclonal banding. The CSF index is the CSF IgG to CSF albumin ratio compared to the serum IgG to serum albumin ratio. The CSF index is therefore an indicator of the relative amount of CSF IgG compared to serum and any increase in the index is a reflection of IgG production in the central nervous system. The IgG synthesis rate is a mathematical manipulation of the CSF index data and can also be used as a marker for CNS inflammatory diseases
"
The index is independent of the activity of the demyelinating process.
Elevation of IgG levels in the cerebrospinal fluid (CSF) of patients with inflammatory diseases of the central nervous system (CNS) (multiple sclerosis, neurosyphilis, acute inflammatory polyradiculoneuropathy, subacute sclerosing panencephalitis) is due to local (CNS) synthesis of IgG.
The two most commonly used diagnostic laboratory tests for multiple sclerosis are CSF index and oligoclonal banding. The CSF index is the CSF IgG to CSF albumin ratio compared to the serum IgG to serum albumin ratio. The CSF index is therefore an indicator of the relative amount of CSF IgG compared to serum and any increase in the index is a reflection of IgG production in the central nervous system. The IgG synthesis rate is a mathematical manipulation of the CSF index data and can also be used as a marker for CNS inflammatory diseases
"
