| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Dibucaine Number
MessageLabCorp
Test Code
81513
Alias/See Also
Dibucaine Inhibition
CPT Codes
82638
Includes
"Dibucaine percent inhibition only
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Preferred Specimen
"Serum or plasma
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Minimum Volume
"0.2 mL
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Other Acceptable Specimens
plasma
Instructions
"Do not collect within 24 hours of administration of muscle relaxant.
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Transport Container
"Red-top tube, gel-barrier tube, or lavender-top (EDTA) tube
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Transport Temperature
"Refrigerate at 2°C to 8°C.
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Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
"Plasma or serum not separated from cells; frozen whole blood received; hemolysis
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Methodology
"Cholinesterase by spectrophotometry (Ellman) with dibucaine inhibition "
Limitations
"No single simple test currently exists that can detect all enzyme variants
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Reference Range
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Normal: 70% to 90% inhibition; heterozygotes: 30% to 70% inhibition; homozygotes: 0% to 30% inhibition
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Normal: 70% to 90% inhibition; heterozygotes: 30% to 70% inhibition; homozygotes: 0% to 30% inhibition
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Clinical Significance
"Assess the presence of homozygous or heterozygous “atypical” cholinesterase variant, in patients who have low result of serum or plasma cholinesterase assay, and may be at risk of apnea when given succinylcholine muscle relaxant
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