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ZONISAMIDE(ZONEGRAN), SERUM
Test Code7915
Alias/See Also
Zonegran
CPT Codes
80203
Preferred Specimen
Serum
Minimum Volume
"0.4 ML (Note: This volume does not allow for repeat testing.)
"
"
Other Acceptable Specimens
plasma
Instructions
Separated serum from cells within 45 minutes of collection and transfer to a plastic transport tube. Separate plasma immediately and transfer to a plastic transport tube for shipment to the laboratory. Trough: Immediately prior to next dose. Steady-state levels are reached within 5 to 15 days in patients on zonisamide monotherapy.
Transport Container
Red-top tube or lavender-top (EDTA) tube. Do not use a gel-barrier tube.
Transport Temperature
Refrigerate at 2°C to 8°C if specimen is not tested immediately
Specimen Stability
14 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gel-barrier tube; hemolysis; nonseparated serum or plasma specimen
Methodology
Liquid chromatography/tandem mass spectrometry (LC/MS-MS)
Limitations
Zonisamide is contraindicated in patients who have demonstrated hypersensitivity to sulfonamides or zonisamide. Consideration should be given to discontinuing zonisamide in patients who develop an otherwise unexplained rash. If the drug is discontinued, patients should be observed frequently.
Reference Range
10.0-40.0 µg/mL
