| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
CLONAZEPAM (KLONOPIN(R)),SERUM
Test Code71712
Alias/See Also
Klonopin®
CPT Codes
80154
Preferred Specimen
"Serum or plasma
4 mL "
4 mL "
Minimum Volume
1.1 mL
Instructions
"Transfer separated serum or plasma to a plastic transport tube. Collect specimen immediately prior to next dose unless specified otherwise.
"
"
Transport Container
"Red-top tube, lavender-top (EDTA) tube, or green-top (heparin) tube. Do not use a gel-barrier tube. The use of gel-barrier tubes is not recommended due to slow absorption of the drug by the gel. Depending on the specimen volume and storage time, the decr
Transport Temperature
Refrigerated
Specimen Stability
"
Room temperature----14 days
Refrigerated----14 days
Frozen-----14 days
"
Room temperature----14 days
Refrigerated----14 days
Frozen-----14 days
"
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
"Gel-barrier tube
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"
Methodology
"Liquid chromatography/tandem mass spectrometry (LC/MS-MS) "
Reference Range
"Therapeutic: 15-60 ng/mL
Critical Values:
Potentially toxic: >80 ng/mL
"
Critical Values:
Potentially toxic: >80 ng/mL
"
Clinical Significance
"Evaluate toxicity; monitor therapeutic levels
Serum peak levels occur approximately two hours after oral administration. The apparent half-life after a single oral dose is 20 to 40 hours. Active metabolites have longer half-lives than the parent drug. Half-lives are increased in the elderly. Therapeutic effect is not well correlated with serum levels. Effect of CNS depressants may be augmented by concomitant use of this agent. This drug is used as an anticonvulsant. It is useful in reducing tardive dyskinesia.1
"
Serum peak levels occur approximately two hours after oral administration. The apparent half-life after a single oral dose is 20 to 40 hours. Active metabolites have longer half-lives than the parent drug. Half-lives are increased in the elderly. Therapeutic effect is not well correlated with serum levels. Effect of CNS depressants may be augmented by concomitant use of this agent. This drug is used as an anticonvulsant. It is useful in reducing tardive dyskinesia.1
"
