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CARNITINE, TOTAL AND FREE
Test Code706500
Alias/See Also
"Carnitor®/Carnitor® SF
L-Carnitine®
Levocarnitine
"
L-Carnitine®
Levocarnitine
"
CPT Codes
82379
Preferred Specimen
"Serum or plasma
2.5 mL
"
2.5 mL
"
Minimum Volume
"1.5 mL
"
"
Instructions
"Transfer separated serum or plasma to a plastic transport tube and freeze. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.
"
"
Transport Container
"Red-top tube, gel-barrier tube, or green-top (heparin) tube
"
"
Transport Temperature
Frozen
Specimen Stability
"Frozen
14 days"
14 days"
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
"
Specimen not frozen
"
Specimen not frozen
"
Methodology
"High-pressure liquid chromatography/tandem mass spectrometry (LC/MS-MS) "
Clinical Significance
"Evaluate various muscle disorders
L-carnitine is a normal component of human serum. Its concentrations are altered in patients with acute muscular necrosis, kidney disease, systemic carnitine deficiency, and diabetes mellitus. L-carnitine (t-trimethylamino-(ß)-hydroxybutyric acid) is essential for the transport of free fatty acids into mitochondria and hence to the site of fatty acid oxidation for energy production from fat. Carnitine deficiency has been associated with several cases of myopathy and may play an important role in at least some disorders of lipid metabolism.
"
L-carnitine is a normal component of human serum. Its concentrations are altered in patients with acute muscular necrosis, kidney disease, systemic carnitine deficiency, and diabetes mellitus. L-carnitine (t-trimethylamino-(ß)-hydroxybutyric acid) is essential for the transport of free fatty acids into mitochondria and hence to the site of fatty acid oxidation for energy production from fat. Carnitine deficiency has been associated with several cases of myopathy and may play an important role in at least some disorders of lipid metabolism.
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