| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
EVEROLIMUS
Test Code700003
CPT Codes
80169
Preferred Specimen
"Whole blood
2 mL"
2 mL"
Minimum Volume
0.5 mL
Transport Container
"Lavender-top (EDTA) tube or green-top (heparin) tube
"
"
Transport Temperature
refrigerated
Specimen Stability
"Room temperature---14 days
Refrigerated---14 days
Frozen---14 days
Freeze/thaw cycles---Stable x3"
Refrigerated---14 days
Frozen---14 days
Freeze/thaw cycles---Stable x3"
Methodology
"Liquid chromatography/tandem mass spectometry (LC-MS/MS) "
Clinical Significance
"Everolimus is a proliferation signal inhibitor that prevents allograft rejection. It exerts its immunosuppressive effect by inhibiting the proliferation, and thus clonal expansion, of antigen-activated T cells, which is driven by T-cell-specific interleukins. Everolimus inhibits an intracellular signaling pathway that is triggered up binding of these T-cell growth factors to their respective receptors, and which normally leads to cell proliferation. The blockage of this signal by everolimus leads to an arrest of the cells at the G1 stage of cell cycle.
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