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THYROID PEROXIDASE (TPO) AB
Test Code6676
Alias/See Also
"Antimicrosomal Antibody
Antithyroid Microsomal Antibody
Thyroid Peroxidase Autoantibodies
TPO Antibodies
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Antithyroid Microsomal Antibody
Thyroid Peroxidase Autoantibodies
TPO Antibodies
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CPT Codes
86376
Preferred Specimen
Serum 0.8 mL
Minimum Volume
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0.3 mL (Note: This volume does not allow for repeat testing.)
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0.3 mL (Note: This volume does not allow for repeat testing.)
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Instructions
"If red-top tube is used, transfer separated serum to a plastic transport tube.
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Transport Container
"Red-top tube or gel-barrier tube
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Transport Temperature
Refrigerated
Specimen Stability
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Room temperature----14 days
Refrigerated----14 days
Frozen----14 days
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Room temperature----14 days
Refrigerated----14 days
Frozen----14 days
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Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
"Citrate plasma specimen; improper labeling
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Methodology
"Electrochemiluminescence immunoassay (ECLIA) "
Limitations
"Should be used in conjunction with antithyroglobulin test, since autoimmune thyroiditis may demonstrate a response to antigens other than thyroid microsomes. To order both antithyroglobulin and antimicrosomal tests, use profile 006684. Other autoimmune disorders such as Sjögren's syndrome, lupus erythematosus, rheumatoid arthritis, pernicious anemia, and others may be positive for antimicrosomal and antithyroglobulin. Patients with myxedema, granulomatous thyroiditis, nontoxic nodular goiter, and thyroid carcinoma may occasionally produce thyroid antibodies.
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Reference Range
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Age-------------(IU/mL)
0-6 d----------0-117
7 d to 3 mo-------0-47
4-11 mo--------0-32
1-5 y-----------0-13
6-10 y----------0-18
11-19 y---------0-26
>19 y----------0-34
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Age-------------(IU/mL)
0-6 d----------0-117
7 d to 3 mo-------0-47
4-11 mo--------0-32
1-5 y-----------0-13
6-10 y----------0-18
11-19 y---------0-26
>19 y----------0-34
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Clinical Significance
"Differential diagnosis of hypothyroidism and thyroiditis
Antibodies to thyroid microsomes (thyroid peroxidase) are present in 70% to 90% of patients with chronic thyroiditis. They are also present in smaller percentages of patients of other thyroid diseases. Antibody production may be confined to lymphocytes within the thyroid, and serum may be negative. Small numbers (3%) of people with no evidence of disease may have antibody. This is more frequent in females and increases with age.
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Antibodies to thyroid microsomes (thyroid peroxidase) are present in 70% to 90% of patients with chronic thyroiditis. They are also present in smaller percentages of patients of other thyroid diseases. Antibody production may be confined to lymphocytes within the thyroid, and serum may be negative. Small numbers (3%) of people with no evidence of disease may have antibody. This is more frequent in females and increases with age.
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