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ANTIEXTRACTABLE NUCLEAR AG
Test Code6338
Alias/See Also
"Anti-ENA
Anti-RNP
Anti-Sm
Anti-Smith
"
Anti-RNP
Anti-Sm
Anti-Smith
"
CPT Codes
86235(x2)
Includes
"Semiquantitative result of IgG class antibodies
"
"
Preferred Specimen
"Serum
1 mL
"
1 mL
"
Minimum Volume
"0.5 mL (Note: This volume does not allow for repeat testing.)
"
"
Transport Container
"Red-top tube or gel-barrier tube
"
"
Transport Temperature
Room temp
Specimen Stability
"
Room temperature
14 days
Refrigerated
14 days
Frozen
14 days
Freeze/thaw cycles
Stable x3
"
Room temperature
14 days
Refrigerated
14 days
Frozen
14 days
Freeze/thaw cycles
Stable x3
"
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
"Hemolysis; icterus; lipemia; bacterial contamination
"
"
Methodology
"Multiplex flow immunoassay "
Reference Range
"0.0-0.9 AI
"
"
Clinical Significance
"Detect antibodies associated with SLE and mixed connective tissue disease. Anti-Sm is highly specific for SLE. Anti-RNP is found with a variety of rheumatoid diseases with high titers associated mainly with MCTD.
Antibodies that produce a speckled ANA pattern are usually directed against extractable nucleoprotein complexes found in the nucleus and/or cytoplasm of substrate cells. Included in this group of antigens are RNP, Sm, SS-A, SS-B, Scl-70, and Jo-1
"
Antibodies that produce a speckled ANA pattern are usually directed against extractable nucleoprotein complexes found in the nucleus and/or cytoplasm of substrate cells. Included in this group of antigens are RNP, Sm, SS-A, SS-B, Scl-70, and Jo-1
"
