Estrogen Receptor/Progesterone Receptor (ER/PR), Immunohistochemical, Paraffin Block

Test Code

480277

CPT Codes
88360(x2)

Includes

"Estrogen receptor analysis; progesterone receptor analysis
"

Preferred Specimen

"Formalin-fixed, paraffin-embedded (FFPE) tumor
"

Minimum Volume

"One paraffin block or seven unstained, positively-charged tissue slides cut at 4-5 microns and dried for one hour at 60°C
"

Instructions

"Maintain specimen at room temperature.
Specimen should be fixed in 10% neutral-buffered formalin within 20 minutes of collection. Optimum fixation time is 12 to 24 hours, not to exceed 48 hours.
Please direct any questions regarding this test to oncology customer service at 800-345-4363.
"

Transport Container

"Paraffin block transport pouch or slide mailer
"

Methodology
"Immunohistochemistry (IHC). This is a semiquantitative measurement of ER/PR positive tumor nuclei in stained histologic tissue sections. "

Limitations

"In the absence of internal positive control staining, a false-negative result cannot be excluded. The presence or absence of positive internal control staining is indicated on all negative reports. Use of fixatives other than 10% formalin may not yield equivalent or satisfactory results.
"

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.