| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
TSH
Test Code4259
CPT Codes
84443
Preferred Specimen
serum
Minimum Volume
0.3
Transport Container
"Red-top tube or gel-barrier tube
"
"
Transport Temperature
refrigerate
Specimen Stability
14 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
"Citrate plasma specimen; improper labeling
"
"
Methodology
"Electrochemiluminescence immunoassay (ECLIA) "
Limitations
"
Spurious increase from antibovine TSH antibodies by double-antibody technique has been reported.2 TSH may be affected by glucocorticoids, dopamine, and by severe illness,3 and these remain limitations even for the new, sensitive TSH assays. TSH suppression in hypothyroidism with severe illness has been reported with TSH increase with recovery.4 Normal TSH levels in the presence of hypothyroidism have been reported with head injury.5 Iopanoic acid, ipodate, and an antiarrhythmic drug, amiodarone, cause changes in thyroid test results including increases in T4, free T4, and TSH and decreases of T3.6 TSH is not elevated in secondary hypothyroidism.
Probably no single test, even the sensitive immunoassays, can be expected to adequately reflect thyroid status under all circumstances. Among possible problems are the recovery phase of nonthyroidal illness, states of resistance to thyroid hormone, thyrotropin-producing tumors, thyroid status in acute psychiatric illness, early in thyrotoxicosis and in subacute thyroiditis.7
"
Spurious increase from antibovine TSH antibodies by double-antibody technique has been reported.2 TSH may be affected by glucocorticoids, dopamine, and by severe illness,3 and these remain limitations even for the new, sensitive TSH assays. TSH suppression in hypothyroidism with severe illness has been reported with TSH increase with recovery.4 Normal TSH levels in the presence of hypothyroidism have been reported with head injury.5 Iopanoic acid, ipodate, and an antiarrhythmic drug, amiodarone, cause changes in thyroid test results including increases in T4, free T4, and TSH and decreases of T3.6 TSH is not elevated in secondary hypothyroidism.
Probably no single test, even the sensitive immunoassays, can be expected to adequately reflect thyroid status under all circumstances. Among possible problems are the recovery phase of nonthyroidal illness, states of resistance to thyroid hormone, thyrotropin-producing tumors, thyroid status in acute psychiatric illness, early in thyrotoxicosis and in subacute thyroiditis.7
"
Reference Range
"
0-6 d
0.700-15.200
7-3 mo
0.720-11.000
3 mo 1 d to 12 mo
0.730-8.350
1 y to 5 y
0.700-5.970
6-10 y
0.600-4.840
>10 y
0.450-4.500
"
0-6 d
0.700-15.200
7-3 mo
0.720-11.000
3 mo 1 d to 12 mo
0.730-8.350
1 y to 5 y
0.700-5.970
6-10 y
0.600-4.840
>10 y
0.450-4.500
"
