| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
TPMT Enzyme
MessagePrometheus
Test Code
3320
CPT Codes
82657, 82491
Preferred Specimen
Whole blood 5.0 mL
Other Acceptable Specimens
EDTA / Lavender Top Tube
Instructions
Informed concent required
Transport Container
original tube
Transport Temperature
Refrigerate; Ship with cold pack (DO NOT FREEZE)
Specimen Stability
7-8 days refrigerated; 24 hours ambient
Report Available
3 business days from date of receipt
Reference Range
"Normal TPMT Activity: >21.0 EU/mL; Intermediate TPMT Activity: 6.0-21.0 EU/mL;
Low TPMT Activity: <6.0 EU/mL"
Low TPMT Activity: <6.0 EU/mL"
Clinical Significance
PROMETHEUS® TPMT Enzyme testing provides a quantitative analysis of a patient’s thiopurine methyltransferase (TPMT) enzyme activity level. Because each patient metabolizes thiopurines differently, the efficacy and toxicity of thiopurines can vary widely from patient to patient. Knowledge of the TPMT enzyme phenotype may reduce time of response, allow physicians to individualize dosing, identify patients in whom thiopurine therapy should be avoided and help reduce the risk of leukopenia.
