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Athena #818 MEN1 DNA Sequencing
MessageHemolysis may compromise DNA recovery after 48 hrs
Test Code
818
CPT Codes
81405(1)
Preferred Specimen
whole Blood
Minimum Volume
10 mL (pediatric minimum: 2 mL)
Instructions
Overnight at room temperature (specimen arrival must be less than 24 hrs after collection)
Transport Container
yellow or lav(EDTA)
Transport Temperature
Room Temp
Specimen Stability
Refrigerated For short periods (until shipped) at 4?C
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
freezing
Methodology
Polymerase Chain Reaction (PCR), DNA sequencing of entire protein coding region of the MEN1 gene
Setup Schedule
M-Th
Report Available
28 days
Reference Range
No mutation detected
Clinical Significance
"Type of Disorder: Family Cancer Syndromes
Typical Presentation: Hyperparathyroidism, Zollinger Ellison syndrome, pituitary disease
Indications for Testing: Tumors in at least two of three target tissues (parathyroid glands, anterior pituitary, duodenum/pancreas); Multiple parathyroid tumors before age 30; Familial idiopathic hyperparathyroidism (FIHPT); Zollinger Ellison syndrome; Family history of MEN1 or FIHPT
Disease(s) tested for: Multiple Endocrine Neoplasia Type 1, Zollinger Ellison Syndrome, Familial Idiopathic Hyperparathyroidism
Detects mutations in the coding sequence of MEN1"
Typical Presentation: Hyperparathyroidism, Zollinger Ellison syndrome, pituitary disease
Indications for Testing: Tumors in at least two of three target tissues (parathyroid glands, anterior pituitary, duodenum/pancreas); Multiple parathyroid tumors before age 30; Familial idiopathic hyperparathyroidism (FIHPT); Zollinger Ellison syndrome; Family history of MEN1 or FIHPT
Disease(s) tested for: Multiple Endocrine Neoplasia Type 1, Zollinger Ellison Syndrome, Familial Idiopathic Hyperparathyroidism
Detects mutations in the coding sequence of MEN1"
