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Dilated Cardiomyopathy (DCM): TNNT2 (Full Gene Sequencing)
MessageLabCorp
Test Code
252347
CPT Codes
81406
Includes
"This test covers all coding nucleotides of gene TNNT2, plus at least two and typically 20 flanking intronic nucleotides upstream and downstream of each coding exon, covering the conserved donor and acceptor splice sites, as well as typically 20 flanking
Preferred Specimen
"Whole blood; DNA is accepted (Call Correlagen at 781-647-0604 for DNA collection information.)
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Minimum Volume
"2 mL
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Instructions
"In cases in which there is a known mutation that can be documented, the physician may prefer to order test 252599.
For all Correlagen tests, specimens must be accompanied by a completed consent form. In the case of family tests (ie, known mutations), Correlagen requires the result report of the first patient tested in the family (the index case), if not performed at Correlagen. Other family members are subsequently tested for the specific mutation found in the first patient tested.
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For all Correlagen tests, specimens must be accompanied by a completed consent form. In the case of family tests (ie, known mutations), Correlagen requires the result report of the first patient tested in the family (the index case), if not performed at Correlagen. Other family members are subsequently tested for the specific mutation found in the first patient tested.
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Transport Container
"Lavender-top (EDTA) tube
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Transport Temperature
"Maintain specimen at room temperature.
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Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
"Container broken or leaking; container not labeled or label not legible
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Methodology
"DNA sequencing "
Limitations
"This method does not reliably detect mosaic variants; large deletions; large duplications, inversions, or other rearrangements; or deep intronic variants. It may be affected by allele-dropout, it may not allow determination of the exact numbers of T/A or microsatellite repeats, and it does not allow any conclusion as to whether two heterozygous variants are present on the same or on different chromosome copies.
Results of this test are for investigational purposes only. The performance characteristics of this assay have been determined by LabCorp. The result should not be used as a diagnostic procedure without confirmation of the diagnosis by another medically established diagnostic product or procedure.
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Results of this test are for investigational purposes only. The performance characteristics of this assay have been determined by LabCorp. The result should not be used as a diagnostic procedure without confirmation of the diagnosis by another medically established diagnostic product or procedure.
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